Applying the rigor of pharmacology to natural cognitive enhancement.

Our Process
Our Formulas
Ingredients
Testing
Sources

An informed hypothesis.

Thesis’ science team and board of scientific advisors are constantly iterating based on our own data, new studies and cognitive research. Every process begins with a systematic review of literature that helps inform a hypothesis we set out to validate at scale. We then formulate based on these hypotheses.

Blind trials.

With formulas in hand, we conduct a series of two week long blind trials. Hundreds of participants receive our formulas and a questionnaire based on a set of scientific criteria designed to standardize the results.

Analyze and iterate.

At the end of a trial all data is analyzed to determine the most effective formulation and that formula is rolled at a larger scale, evaluated again and improved if necessary. Product development is a continuous process at Thesis, we’re always iterating, testing and improving.

Guaranteed results or your money back.

We’re confident in our products and their precise blend of ingredients because they’ve gotten real results for millions of customers. We offer a money-back guarantee that a Thesis product will work for you—and if an existing product we offer won’t, we’ll work with you to develop one that does.

With Clarity, feel 54% more focused or get your money back.

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With Motivation, feel 48% more focused or get your money back.

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With Stress Reset, feel 63% less stressed or get your money back.

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With Neuroprotection, feel 50% less forgetful or get your money back.

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Clinically researched. Precisely formulated.

Thesis uses isolated, plant-derived compounds rather than blends or extractions. This allows us to control consistency and experiment to determine the most effective dose of each ingredient to get the best results possible.

Higher than
other nootropics

Our approach removes the variables by isolating active ingredients in price ratios, and meticulously standardizing the dosage in each Thesis product. And our standardized ingredient thresholds are 4x higher than other nootropics out there.

Clinically researched. Precisely formulated.

Higher than

other nootropics

Thesis runs 10 trials per year on average.

Higher than other nootropics

Fig B. Clarity 4-ingredient formula

Many nootropics make baseless claims.  

We conduct real-world testing.

We conduct continuous beta testing and open-label trials to assess real-world effectiveness. Our studies are designed with the rigor and ethical standards typically reserved for pharmaceutical clinical trials.

30+

Beta Tests

Thesis has run over 30 beta tests
with real customers.

700+

Studies

Thesis reads and analyzes 700+
studies when formulating.

7.3M

Customers

Thesis products have been evaluated
by 7.3 million customers.

We’re devoted to continual improvement.

Our process is driven by two questions: why and how. We’re constantly reevaluating every decision we’ve made, and asking new questions in search of better outcomes for those who love and trust Thesis.

Here are the latest questions that drive what we do:

Modern life hijacks attention with constant pings, scrolls, and dopamine spikes. Clarity targets this head-on by combining Citicoline, Lion’s Mane, and 7,8-DHF to promote neuroplasticity, acetylcholine signaling, and dopamine regulation. This stack helps support distraction resistance, sustained attention, and the deep work required for modern cognitive demands.

Cognitive health isn’t just about a better workday. It’s about protecting what makes you you. From dopamine and Acetylcholine for daily drive and focus, to Sulforaphane, Spermidine, and mitochondrial activators for long-term resilience, our formulas are designed to support both high performance today and brain longevity tomorrow.

Stress Reset combines Shoden® Ashwagandha, clinically shown to reduce cortisol by up to 67% and occasional anxiety by 59%, with Zembrin® and Salidrosides for sharper mood regulation and cognitive flexibility. This version supports serotonin, dopamine, and alpha wave activity, without sedation or crash.

Here’s what we’re reading, if you’re curious, too:

THE NEW YORK TIMES

Generation Adderall

THE NEW YORK TIMES

Stop Letting Modern Distractions Steal Your Attention

THE WALL STREET JOURNAL

‘Super Agers’ Review: Living the Good Life

THE DOSE

Your guide to better brain health